Intracellular GSH Depletion Triggered Mitochondrial Bax Translocation to Accomplish Resveratrol Induced apoptosis in U937 cell Line
نویسندگان
چکیده
Affiliations: Department of Biochemistry, Dr. B.C. Roy Post Graduate Institute of Basic medical Sciences & I.P.G.M.E.&R, 244B, Acharya Jagadish Chandra Bose Road, Kolkata700020, India (P. G., A. D. and S. K. B.), Department of Pharmacology, Dr. B.C. Roy Post Graduate Institute of Basic medical Sciences & I.P.G.M.E.&R, Kolkata-700 020 (R. S. and M. C.), Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India (S. C.) JPET Fast Forward. Published on September 27, 2010 as DOI:10.1124/jpet.110.171983
منابع مشابه
Intracellular GSH depletion triggered mitochondrial Bax translocation to accomplish resveratrol-induced apoptosis in the U937 cell line.
We have previously demonstrated that resveratrol (Resv)-induced cellular apoptosis occurs after formation of reactive oxygen species (ROS) but the role of GSH has not been well defined. Our experimental data enumerated that Resv treatment (50 μm) induced apoptosis in human leukemic monocyte lymphoma cells, which was preceded by cellular GSH efflux. High concentration of extracellular thiol (GSH...
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